
Paulo Dybala found the best corner from Cristiano Ronaldo's go to put the hosts ahead at the Allianz Stadium.
Leonardo Bonucci constrained home after a goalmouth scramble, before Ronaldo scored his 21st objective of the period in all rivalries.
Federico Bernardeschi was ruined by Frosinone goalkeeper Marco Sportiello in stoppage time.
Second-set Napoli face Torino at home on Sunday.
Massimiliano Allegri's Juventus side travel to Atletico Madrid on Wednesday in the main leg of their Champions League last-16 tie.
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